Melatonin Efficacy in Mitigating Infectious Diseases

November 23, 2021

A new study demostrates that melatonin is beneficial in preventing complications, and in reducing the mortality rate in patients with covid-19.

A new study from a group of Iraqi researchers demostrates that melatonin is beneficial in preventing complications in people with covid-19, and in reducing the mortality rate in patients with covid-19. New research, entitled, “The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in covid-19 Patients”, was published in the “International Journal of Infectious Diseases.”

“The purpose of this study”, authors write, “is to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (covid-19).”

“This single-center, prospective, randomized clinical trial was conducted from 1 December 2020 to 1 June 2021 at Al-Shifaa hospital in Mosul, Iraq. There were 158 patients with severe covid-19 included in the study, 82 in the melatonin group (who received 10 mg melatonin per day – in addition to standard therapeutic care), and 76 in the control group (given standard therapeutic care only). Patients were chosen by blocked randomization design. The physician then evaluated and recorded the incidence of thrombosis, sepsis, and mortality rate on days 5, 11, and 17 of symptoms.”

The intervention group consisted of 82 patients, while the control group consisted of 76 patients. In comparison to the control group, thrombosis and sepsis developed significantly less frequently (P < 0.05) in the melatonin group during the second week of infection, while mortality was significantly higher in the control group (P < 0.05). Adjuvant use of Melatonin may help reduce thrombosis, sepsis, and mortality in covid-19 patients.”

“Thrombotic complication”, they explain, “are common in covid-19 and are associated with a significant increase in mortality and morbidity. Covid-19 may enhance sepsis-induced hypercoagulability. … Melatonin is a multifunctional molecule that has been shown to have antioxidant, anti-inflammatory, and immunomodulatory properties. Melatonin has been shown to be involved in the regulation of sleep and blood pressure, as well as in the improvement of viral respiratory disorders. … However, there is a limited number of clinical and laboratory studies on the adjunctive use of melatonin in covid-19 infection. … Thus, a randomized clinical trial was designed and conducted in this study to compare the efficacy of adding oral melatonin to standard treatment in hospitalized adult patients with severe covid-19 infection.”

“The results of this study”, authors conclude, “demonstrated that oral melatonin, when added to standard of care, was more effective than standard of care alone in patients hospitalized with severe covid-19. Improved thrombosis, sepsis, and mortality rates support the adjuvant melatonin’s efficacy in mitigating this infectious disease. Given melatonin’s superior performance as a cheap, highly safe, and readily available medication, it is strongly recommended to be addressed in future studies.”

Full Study, titled “The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in covid-19 Patients”